Precision laser cut and laminated layers used to create and optimize microfluidic devices;
incorporate membranes, valves, and pumps. Track record of success in development of
Lab-on-a-Chip, Point of Care, and fieldable devices.
We manufacture under an FDA compliant Quality System
Flowcells and multiplexed systems that interface to optical and electrochemical sensors. Demonstrated applications in cell lysis, cell sorting, and bacterial capture and analysis for multiple clients. Our proprietary know-how and experience with biological systems means you get a working prototype right away.
Bio-compatible materials allow heart muscle cells to grow to confluence and beat normally in our MicroSlide product. Pnuematically controlled valves support low dead volume, multi-step analyses with on-board reagents.
Offering full-service design, modeling, and fabrication of Lab-on-a-Chip devices. Volume manufacture to 500,000 parts/year. Proven materials for applications in cell culture - Robust enough for applications in space. See publications: NASA Card (PDF:116K)
ALine provides its customers in the areas of medical research, medical instrumentation, medical diagnostics, laboratory instrumentation, field instrumentation, and flight rated equipment with a sophisticated array of standard and custom bio micro solutions based on its versatile, bio compatible, precision laser cut, multilayer polymer laminate manufacturing technology. Applications include spectroscopy, environmental analysis, membrane separations, antibiotic response, cell toxicity, automated cell culture, and multiplexed drug matrix analysis.
ALine’s flagship standard product, the FluoroVette™, provides an easy to fill micro volume sample chamber with a short path, UV transparent, optical window that is ready to be mounted on a standard microscope stage or simply slipped into a companion adapter and mounted in the measurement port of a standard spectrofluorometer. Far more economical and easy to use than a quartz cuvette, ALine’s disposable FluoroVette™ comes in a number of micro volume, fill port, and UV transparency options
ALine’s custom bio-micro products range from enhancements to the popular Fluorovette™ to the design, prototyping, and volume production of sophisticated bio micro fluidic cards. Whether it is the stat analysis of antibiotic resistant bacteria for a patient with sepsis, the point of care diagnosis of a specific carrier gene for genetic counseling, or the leading edge research for a pharmaceutical company, custom bio micro fluidic cards can provide a superior solution.
One of ALine’s custom bio micro cards has successfully been flown on NASA Ames’ GenSat-1 mission in support of multiplexed cell cultures in a nanosatellite, zero gravity experiment. Using its naturally rugged bio compatible lamination method, ALine assembled a 12 well, bio micro cell culture card using sheets and films of bio compatible material that were laser cut to the custom design requirements. A key to the success was the development of an advanced process for inserting porous membranes.
